Inhibitory effect of 2-(2-fluoro-4-biphenylyl) propionic acid (Flurbiprofen) on prostaglandin synthesis
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منابع مشابه
2-[(4-Methylbenzoyl)hydrazono]propionic acid monohydrate
In the title compound, C(11)H(12)N(2)O(3)·H(2)O, the water mol-ecule is a hydrogen-bond donor to the double-bond amide and the carbonyl O atoms of two acid mol-ecules; it is also a hydrogen-bond acceptor to the acid -OH and amide -NH- groups. These hydrogen-bonding inter-actions give rise to a layer structure, with the layers parallel to the ab plane.
متن کامل2-[(4-Chlorobenzoyl)hydrazono]propionic acid monohydrate
In the title compound, C(10)H(9)ClN(2)O(3)·H(2)O, the water mol-ecule is a hydrogen-bond donor to the amide and carbonyl O atoms of two acid mol-ecules; it is also a hydrogen-bond acceptor to the acid OH group and the amide H atom. The hydrogen-bonding inter-actions give rise to a two-dimensional array.
متن کاملA comparative study of flurbiprofen and aspirin in soft tissue trauma.
A double blind study using flurbiprofen (2-(2-fluoro-4-biphenylyl propionic acid) 150 mg daily and soluble aspirin (3.6 g daily) for 5 days immediately after injury, was carried out in 52 soft tissue injuries to the lower limb in professional sportsmen. Flurbiprofen was more effective than aspirin in producing analgesia (when daily pain scores were considered) after day 2 (p less than 0.02); an...
متن کامل6-Fluoro-4-oxochroman-2-carboxylic acid
The title compound, C(10)H(7)FO(4), is an inter-mediate in the synthesis of the drug Fidarestat, (2S,4S)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione. The di-hydro-pyran-one ring adopts an envelope conformation with the asymmetric C atom in the flap position. In the crystal, the mol-ecules are linked into zigzag chains along [100] by O-H⋯O hydrogen bonds and C-H⋯π inter-...
متن کامل2-Fluoro-4-(methoxycarbonyl)benzoic acid
In the crystal of the title compound, C(9)H(7)FO(4), classical carboxylate inversion dimers are linked by pairs of O-H⋯O hydrogen bonds. The packing is consolidated by C-H⋯F and C-H⋯O interactions. The benzene ring and the methoxycarbonyl group are nearly coplanar, with a dihedral angle of 1.5 (3)° between them, whereas the carboxyl group has a dihedral angle of 20.2 (4)° with respect to the be...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1976
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.72.1025